Toltrazuril for EPM in Horses: An Effective Treatment Option with

Equine protozoal myeloencephalitis (EPM) is a debilitating neurological disease affecting horses, caused by the protozoan parasite Sarcocystis neurona, typically transmitted by opossums. EPM can lead to muscle atrophy, weakness, incoordination, lameness, and, in severe cases, paralysis or death. Traditional treatments such as sulfadiazine and pyrimethamine can be ineffective and carry significant side effects.

Enter Toltrazuril, a promising anti-protozoal drug showing remarkable efficacy in treating EPM in horses. This article delves into Toltrazuril’s use for EPM, its mechanism of action, dosage, safety, and how to access it through, a leading online source.

What is Toltrazuril?

Toltrazuril is a triazine-based anti-protozoal drug well-established for treating coccidial infections in various animals. It targets Sarcocystis neurona, the EPM-causing protozoa, by inhibiting essential enzymes within the parasite’s apicoplast, ultimately leading to its demise while sparing the host animal. Toltrazuril is highly specific to apicomplexan protozoa and exhibits minimal toxicity in mammals.

How Does Toltrazuril Work?

Toltrazuril inhibits metabolic enzymes and reduces pyrimidine synthesis within the apicoplast of the protozoan parasite. This effectively leads to the parasite’s demise while leaving the host animal unharmed. Remarkably, Toltrazuril is highly specific to apicomplexan protozoa and exhibits minimal toxicity in mammals. It is also effective against triazine-resistant strains of the parasite.

Dosage of Toltrazuril for EPM in Horses

For EPM treatment in horses, the recommended dosage of Toltrazuril is 20 mg/kg of the horse’s body weight. Administer the drug orally once a day for five consecutive days, ideally with food to enhance absorption. Dosage adjustments may be necessary based on the disease’s severity and the horse’s response to treatment.

Safety of Toltrazuril for Horses

Toltrazuril is generally considered safe for use in horses, boasting a wide safety margin and minimal side effects. However, as with any medication, there is a slight risk of adverse reactions, including gastrointestinal upset, anorexia, lethargy, and allergic responses. These side effects are infrequent and typically mild and self-limiting.

Efficacy of Toltrazuril for EPM in Horses

Multiple studies have validated Toltrazuril’s efficacy in treating EPM in horses. In one clinical trial involving 22 EPM-afflicted horses, Toltrazuril effectively reduced clinical signs and improved neurological function without significant side effects. In another study, Toltrazuril proved as effective as the standard EPM treatment, sulfadiazine and pyrimethamine, in reducing clinical signs and enhancing neurological function.

Comparison with Other Anti-protozoal Drugs

Toltrazuril stands out as a promising treatment for EPM in horses, surpassing other drugs such as sulfadiazine and pyrimethamine in efficacy while causing fewer side effects. Moreover, it remains effective even against triazine-resistant parasite strains, making it a valuable choice for EPM-afflicted horses.


Toltrazuril emerges as a highly effective and safe treatment option for EPM in horses. With its specific activity against Sarcocystis neurona and a well-tolerated profile, it offers hope for afflicted horses and their owners. For those seeking access to this groundbreaking medication, stands as a trusted online resource. Offering Toltrazuril products and expert guidance, facilitates the procurement of this vital tool in EPM management. Consider Toltrazuril as a first-line treatment for EPM in horses and CLICK HERE to order from Your equine companion’s well-being is worth it.


Share on facebook
Share on twitter
Share on linkedin
Leave a Reply

Your email address will not be published. Required fields are marked *


Your Product Basket

Quantity: 0 Items: 0
The Cart is Empty
No Product in the Cart!
Shopping cart close